Once any dark anomalies in the data have successfully been dealt with, operating the Wipe module is fairly straightforward.
By default, a setting is selected that performs well in the presence of moderate gradients, colour casts or bias levels.
If the gradient is found to undulate stronger, a higher 'Aggressiveness' setting may be appropriate. When using a higher 'Aggressiveness', be mindful of Wipe not 'wiping' away any medium to larger scale nebulosity. To Wipe, larger scale nebulosity and a strong undulating gradients can look like the same thing!
If you're worried about Wipe removing any larger scale nebulosity, you can protect this nebulosity by masking it out, so that Wipe doesn't sample it.
Because Wipe's impact on the dynamic range in the image is typically very, very high, a (new) stretch of the data is almost always appropriate so that the freed up dynamic range that used to be occupied by the gradients and/or light pollution can now be put to good use to show detail. Therefore, a global re-stretch using the AutoDev or Develop module is almost always required.
Having to 'Keep' the result and switching to 'AutoDev' or 'Develop', just to see the result, is a bit tedious. Therefore, switching on a courtesy 'Temporary AutoDev' operation allows you to see the result.
You can convert everything you see to a format you find convenient. Give it a try!