In AutoDev, you're controlling an impartial and objective detail detector, rather than a subjective and hard to control (especially in the highlights) bezier/spline curve.
Having something impartial and objective taking care of your initial stretch is very valuable, as it allows you to much better set up a "neutral" image that you can build on with the other local detail-enhancing tools in your arsenal (e.g. Sharp, HDR, Contrast, Decon, etc.). For example, when using Autodev, it will quickly become clear that point lights and over-exposed highlights, such as the cores of bright stars, remain much more defined. The dreaded "star bloat" effect is much less pronounced or even entirely absent, depending on the dataset.
However, knowing how to effectively use Region of Interests ("RoI") is crucial to making the most of AutoDev. Particularly if the object of interest is not image-filling, a Region of Interest will often be necessary. Fortunately the fundamental workings of the RoI are easy to understand.
Let's say our image is of galaxy, neatly situated in the center. Then confining the RoI progressively to the core of the galaxy, the stretch becomes more and more optimised for the core and less and less for the outer rim. Conversely, if we want to show more of the outer regions as well, we would include those regions in the RoI.
Shrinking or enlarging the RoI, you will notice how the stretch is optimised specifically to show as much as possible of the image inside of the RoI. That is not to say any detail outisde the RoI shall be invisible. It just means that any detail there will not (or much less) have a say in how the stretch is made. For example, if we would have an image of a galaxy, cloned it, put the two image side by side to create a new image, and then specified the RoI perfectly over just one of the cloned galaxies, the other one, outside the RoI would be stretched precisely the same way (as it happens to have exactly the same detail). Whatever detail lies outside the RoI, is simply forced to conform to the stretch that was designed for the RoI.
It is important to note that AutoDev will never clip your blackpoints outside the RoI, unless the 'Outside RoI Influence' parameter is explicitly set to 0% (though it is still not guaranteed to clip even at that setting). Detail outside the RoI may appear very dark (and approach 0/black), but will never be clipped.
Bringing up the 'Outside RoI Influence' parameter will let AutoDev allocate the specified amount of dynamic range to the area outside the RoI as well, at the expens of some dynamic range inside the RoI. If 'Outside RoI Influence' set 100%, then precisely 50% of the dynamic range will be used to show detail inside the RoI and 50% of the dynamic range will be used to show detail outside the RoI. Note that, visually, this behavior is area-size dependent; if the RoI is only a tiny area, the area outside the RoI will have to make do with just 50% of the dynamic range to describe detail for a much larger area (e.g. it has to divide the dynamic range over many more pixels), while the smaller RoI area has much fewer pixels and can therefore allocate each pixel more dynamic range if needed, in turn showing much more detail.
This way, nasty noise surprises when viewing the image at 100% are avoided.
In this case the Life module can be used to isolate objects in an image and lift them from an otherwise noisy background.
Bin the image up until each pixel describes one unit of real detail.
'Brightness/Color detail loss' specifies a measure of allowed acceptable detail loss in order to reduce noise.
A global re-stretch using the AutoDev or Develop module is almost always required.
You can convert everything you see to a format you find convenient. Give it a try!