In StarTools, your signal is processed (read and written) in a time-fluid way. Being able to change the past for a better future not only gives you amazing new functionality, changing the past with knowledge of the future also means a cleaner signal. Tracking always knows how to accurately estimate the noise component in your signal, no matter how heavily modified.
Open an image stack ("dataset"), fresh from a stacker.
The De-Noise module offers detail-aware, astro-specific noise reduction, which, paired with StarTools' Tracking feature, yields results that have no equal.
There is no one perfect solution, but rather a range of approximations to the "perfect" solution.
You can convert everything you see to a format you find convenient. Give it a try!